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DHEA (dehydroepiandrosterone) is an endogenous steroid hormone, naturally synthesized by the body. DHEA is one of the most abundant steroid hormones in the human body and is produced by the adrenal glands, gonads and brain. Your body naturally produces the hormone dehydroepiandrosterone (DHEA) in the adrenal gland. In turn, DHEA helps produce other hormones, including testosterone and estrogen. Natural DHEA levels peak in early adulthood and then slowly fall as you age. Production of DHEA peaks between the ages of 20 and 40, and declines from this point onwards. This is the main reason that DHEA is considered an important chemical in the aging process. In theory, taking DHEA supplements to maintain DHEA levels could slow the aging process, possibly improving well-being, cognitive function and body composition. DHEA might be more effective at treating depression than placebo.
Research suggests DHEA might improve bone mineral density in elderly people with low DHEA. But improvements in bone density were small compared with those seen after treatment with approved osteoporosis medications. Limited research suggests that DHEA might improve vaginal dryness in postmenopausal women. Research on the effects of DHEA on well-being and body composition has had mixed results, and most studies indicate no effect of DHEA on cognitive function or on muscle size or strength. In normal circumstances, DHEA is most commonly found in the form of dehydroepiandrosterone sulfate (DHEAS), held in a reservoir and converted when hormones are required. Other than this intermediary role, DHEA is also likely to play a part in other physiological pathways, it is believed to bind to a number of receptor types and act as a neurosteroid. DHEA might eventually prove to have benefits in treating people diagnosed with certain conditions, such as adrenal insufficiency and lupus. The primary role of DHEA is as an intermediary molecule in the synthesis of estrogen and androgen sex hormones.
