What is Melatonin
Melatonin is a metabolite of tryptophan metabolism. It is produced in the pineal gland in the gut and the retina of the eye and central pulsatile release under the influence ofdarkness. Melatonin levels rise in the night by a factor of ten, the maximum is reached about three clock in the morning - with a seasonally changing rhythm. The secretion is held back by daylight. The importance of melatonin in jet lag and shift work is well recognized, application of melatonin is controversial in this context. Through the coordination of circadian-rhythmic processes in the body it exerts its effect as a timer. The melatonin-induced sleep phase is a stimulant for the secretion of growth hormone somatotropin. Such chronic disorders cause premature Somatopause. Other important effects of melatonin are in its effect as an antioxidant, but can not be used therapeutically. Also important is the antigonadotrope effect (reduction is the sex glands), and turn down the many biological and oxidative processes, it is eighth in particular when taking melatonin. Especially a reduction (but also an increase) of melatonin in the blood causes sleep disturbance or disruption of the sleep wake rhythm.
Melatonin and Plants
Melatonin has been identified in many plants including feverfew, St John's wort (Hypericum perforatum). rice, corn, tomato and edible fruits. The physiological roles of melatonin in plants involve regulation of their response to photoperiod, defense against harsh environments, and the function of an antioxidant. Melatonin is endogenously produced and is also consumed in edible plants. In animal experiments, feeding melatonin containing foods raised blood levels of the indole. melatonin has now been found to exist in plants as well. Two major functions of melatonin in animals are dark signaling and antioxidant protection. No consistent evidence was found that melatonin increased significantly in organs of these plants during the night, as it does in many animals. The discovery of melatonin in algae (Poeggeler and Hardeland, 1994) led to speculation that melatonin may be found in a wider range of plant tissues. Melatonin in higher plants was first reported by Hattori. Melatonin was found in all fifteen seeds sampled, the highest levels were found in mustard seeds. Because physiologic concentrations of melatonin in the blood are known to correlate with the total antioxidant capacity of the serum, consuming foodstuffs containing melatonin may be helpful in lowering oxidative stress.
Melatonin and Insomnia
Studies suggest that melatonin supplements may help people with disrupted circadian rhythms and those with low melatonin levels to sleep better. melatonin seemed to help people fall asleep faster, sleep better, be more alert in the morning, and improve quality of life in people with primary insomnia. By the time we're elderly, melatonin levels are quite low, perhaps accounting for the fact that so many older people suffer from insomnia. Studies suggest that melatonin supplements may help people with disrupted circadian rhythms and those with low melatonin levels to sleep better. clinical studies suggests that melatonin supplements may help prevent jet lag. Melatonin is another natural choice to treat insomnia. melatonin is more effective than a placebo in reducing the time it takes to fall asleep, increasing the number of sleeping hours, and boosting daytime alertness.The hormone melatonin in its natural state is a key ingredient in the sleep wake cycle. When your body’s biological clock is in sync with the natural rhythm of the world your melatonin levels increase and decrease along a 24 hour cycle. Insomnia is not a simple problem. For millions it is an ongoing, or chronic, sleep disturbance that has attachments to deeper physical and psychological problems. melatonin are encouraged to begin treatment at a low dose of approximately 30 minutes prior to bedtime.
Melatonin and Immune system
Melatonin reduces tissue destruction during inflammatory reactions by a number of means. Melatonin has a direct stimulatory effect on immune system tissues. Thus melatonin, by virtue of its ability to directly scavenge toxic free radical. melatonin may have immune enhancing, anti inflammatory, and even cancerous cell killing effects in the body. While it is known that melatonin interacts with the immune system, the details of those interactions are unclear. melatonin induces the production of inflammatory cytokines and nitric oxide. There have been few trials designed to judge the effectiveness of melatonin in disease treatment. Melatonin may be used for the stimulation of immune response during viral and bacterial infections. melatonin acting on high affinity receptors expressed in immunocompetent cells. melatonin is a powerful anti oxidant, a compound that blocks the action of free radicals, activated oxygen molecules that can damage cells. melatonin may enhance cytokine production, and by doing this counteract cquired immuno deficiences. Melatonin affects immune function indirectly through its effects on thyroid stimulating hormone. Some studies also suggest that melatonin might be useful fighting infectious disease including viral, such as HIV, and bacterial infections, and potentially in the treatment of cancer. Melatonin influences zinc metabolism, which, in turn, plays a major role in strengthening immune function. Endogenous melatonin in human lymphocytes has been related to interleukin 2 production. Melatonin may protect mice from viral encephalitis, bacterial diseases and septic shock. In rheumatoid arthritis patients, melatonin production has been found increased when compared to age matched healthy controls.
Along with melanocyte stimulating hormone, melatonin controls the dispersion of melanin throughout melanocyte cells. The age related decline of pineal melatonin production is due to the degenerative changes of the neural structures, herbal teas such as peppermint and rooibos if you want to maintain regular melatonin production. biological night reduces melatonin production and release. Melatonin controls pigmentation changes by aggregation of melanin into the melanocytes within the skin, causing the skin to change color. Nightime light exposure disrupts melatonin production and interferes with sleep, Melatonin production gradually declines with age, and its loss is associated with several age related diseases. This is responsible for the change in skin color due to amount of sleep or the appearance of those who are sleep deprived, ust as light during the night interferes with melatonin production, since melatonin also controls the circadian cycle. This interaction is also responsible for the skin color of elderly people, since melatonin production reduces with age, melatonin production as a kind of biological clock that regulates their reproductive cycles on the basis of the length of the solar day, melatonin production is in the evening, when the sky becomes dark. production in the body, melatonin can also be taken in capsule form, melatonin suppression has far worse consequences than simply poor sleep outcomes, Melatonin does not appear to have any negative side effects, doesn’t interfere with memory, concentration.
Melatonin and depression
Melatonin has been shown to be effective in treating one form of depression and seasonal affective disorder, and is being considered for bipolar and other disorders in which circadian disturbances are involved. If you must take melatonin to help with your sleep or mental problems, The link could be due to the production of the hormone melatonin, which is interrupted when you’re exposed to light at night. there is also research that suggests that melatonin supplementation can worsen the state of the disorder, The individuals taking the melatonin improved their mood and lessened their depression, Some people use melatonin for Alzheimer’s disease, ringing in the ears, depression. Melatonin and depression may be linked because melatonin supplements can improve sleep quality, melatonin can be beneficial for those who know they will be up late for a few nights. Melatonin’s immediate precursor is the neurotransmitter serotonin, which is a major player in uplifting your mood, the melatonin analog agomelatine may represent an important new addition to the current array of medications to treat major depression, Like serotonin, there has also been a melatonin depression link, Melatonin is a hormone produced naturally, The combination of melatonin supplements and antidepressant medications can also contribute to increasing depressive symptoms
Melatonin supplement benefits
Melatonin is a product of synthesis exactly identical with the hormone that is produced in the pineal gland and which brings substantial benefits, For insomnia melatonin is the best and safest sleeping pills on the market. It's effective in just one hour with up to 90% of the active ingredient. naturally produced melatonin decline with advancing age, leaving older adults with limited antioxidant protection against conditions associated with oxidative stress, Sleep, which is induced by melatonin is deeper, more relaxing and healthier than that of ordinary sleeping pills. Melatonin is a powerful and versatile antioxidant produced within the body, The melatonin-users always wakes up fresh and rested. Melatonin is especially effective for jet lag (time shift) and complaints related to the change of the day-night rhythm in combination, especially with shift work. Melatonin Improve sleep quality and morning alertness has also been reported. The same applies to the seasonal mood disorders in people whose biorhythms are difficult to adapt to the changing conditions of the seasons, Multiple human studies have measured the effects of melatonin supplements on slee Melatonin neutralizes the effects of stress and reduces the gradual decline of the immune system that accompanies it. Melatonin may be helpful in regulating age-dependent changes in body temperature rhythm, Melatonin is the only antioxidant that can directly penetrate into the brain, since both fat and water soluble, Melatonin is a compound in our body that helps to regulate sleep as well as other physiological rhythms in our body, Many studies show that melatonin can protect against cancer and the dangers of toxic chemotherapy. It provides the functionality of the thymus restores and increases the number of lymphocytes. Research also shows that supplementing with melatonin can reduce high blood pressure, colds can cope better and can stop the effects of the aging process and reduce overall.
Melatoin and SAD
Seasonal affective disorder (SAD), also known as winter depression, winter, summer, depression, summer blues, or seasonal depression, was considered, a mood disorder in some people experience a serious mood change when the seasons change, most of the year experience depressive symptoms in the winter or summer, whereas light too dim to suppress human melatonin is therapeutically ineffective, SAD was formally described and named in 1984 by Norman E. Rosenthal and colleagues at the National Institute of Mental Health, There are many different treatments for classic seasonal affective disorder, including light therapy with sunlight or bright lights carefully timed supplementation of the hormone melatonin, Melatonin level The change in season can disrupt the balance of the natural hormone melatonin, which plays a role in sleep patterns and mood, Another theory is that the cause may be related to melatonin which is produced in dim light and darkness by the pineal gland, since there are direct connections, via the, between the retina and the pineal gland, The researchers write, calling melatonin the chemical signal of darkness, Melatonin secretion is controlled by the endogenous circadian clock, but can also be suppressed by bright light, Those patients responded best when they took melatonin in the morning, Melatonin is a powerful antioxidant more importantly, it is one of the few antioxidants that can penetrate into the cell's mitochondria, Photoperiod related alterations of the duration of melatonin secretion may affect the seasonal mood cycles of SAD, Melatonin has been safely used in humans for years, melatonin suppression and phase shifts equivalent to 10,000 lux bright light therapy in winter depressives.
• Melatonin Helps Regulate Sleep Cycle
• Melatonin Resets Sleep Wake Cycle
• Melatonin Stop or slow the aging
• Melatonin Provides natural support for healthy sleep.
• Melatonin Helps circadian rhythyms normalize after jet lag.
• Melatonin Has a variety of antioxidant activitie
Melatonin can be especially helpful for those who have a hard time falling asleep and wake up, Melatonin may have a role in protecting you against cancer, Melatonin also supports the immune system. Melatonin Its production has many benefits for the body since Melatonin is a powerful and versatile antioxidant that fights some of the most dangerous free radicals in the body, melatonin also plays an important role in gut health. It regulates peristalsis and bowel movements.
• Melatonin is a Natural Sleep Aid.
• Melatonin Treat insomnia.
• Melatonin Enhance sleep quality.
• Melatonin Fight jet lag symptoms.
• Melatonin will Help Prevent Premature Aging.
• Melatonin Relieve symptoms of SAD.
• Melatonin is a Remedy for Jet Lag.
• Melatonin Decrease ocular pressure.
• Melatonin May prevent Parkinson’s Disease.
Melatonin and Obesity
Melatonin is involved in energy metabolism and body weight control in small animals. Many studies show that chronic melatonin supplementation in drinking water reduces body weight and abdominal fat in experimental animals, They found that the melatonin supplemented group experienced a significant reduction in body weight with no difference in calories consumed as compared with the non supplemented subjects, Melatonin might help to prevent cardiovascular disease associated with obesity and dyslipidemia, especially in the middle aged rats and the weight loss effect did not require the animals to eat less and to be physically more active, University of Granada researchers have proven that melatonin a natural hormone produced by the body helps in controlling weight gain even without reducing the intake of food, A potential mechanism is that melatonin promotes the recruitment of brown adipose tissue as well as enhances its activity, Melatonin is found in small quantities in some fruits and vegetables as mustard, This effect would raise the basal metabolic rate by stimulating thermogenesis, heat generation through uncoupling oxidative phosphorylation in mitochondria. Whether the results of animal studies can be extrapolated to human obesity is a matter of future clinical trials, since substantially active BAT has been identified in adult humans.
Melatonin Circadian rhythm:
Exogenous melatonin taken in the evening is, together with light therapy upon awakening, the standard treatment for delayed sleep phase syndrome and non 24 hour sleep-wake syndrome where circadian rhythms are not entrained to the environmental cycle, melatonin receptor stimulant, is also available to treat circadian rhythm disorders, It appears to have some use against other circadian rhythm sleep disorders as well, such as jet lag and the problems of people who work rotating or night shifts. Melatonin reduces sleep onset latency to a greater extent in people with DSPS than in people with insomnia, The first thing to know about melatonin is that its half life is very short, and is only active in your system for about 20 minutes. This is why it is important to use different types of melatonin for different reasons, melatonin has the potential to induce deleterious effects, melatonin may help in the synchronization of biological rhythms to the environment, Melatonin’s versatility is shown in its various physiological functions including immunomodulation, antioxidation, melatonin levels become regular in about the third month after birth.
Melatonin Medical uses
Melatonin has been studied as a potential treatment of gastroesophageal reflux disease, cancer, immune disorders, cardiovascular diseases, depression, seasonal affective disorder (SAD), circadian rhythm sleep disorders, sexual dysfunction and insomnia in the elderly, Prolonged release melatonin has shown good results in treating insomnia in older adults It may ameliorate circadian misalignment and SAD, Basic research indicates that melatonin may play a role in modulating the effects of drugs of abuse such as Melatonin is also a geroprotector, A 2004 review found that melatonin significantly increased total sleep time in people suffering from sleep restriction, For many types of sleep disorders, melatonin is not effective. A 2006 review found that although it is safe for short term use there is "no evidence that melatonin is effective in treating secondary sleep disorders or sleep disorders accompanying sleep restriction, such as jet lag and shiftwork disorder, In a 2005 study, researchers concluded that while "there is some evidence to suggest that melatonin is effective in treating delayed sleep phase syndrome there is evidence to suggest that melatonin is not effective in treating most primary sleep disorders with short term use
Melatonin has a pivotal role in regulating body temperature, female reproductive hormones, the sleep, wake cycle, and cardiovascular function, melatonin appears to be most beneficial to those individuals who are not producing adequate levels themselves, Abnormalities of melatonin circadian function have been closely linked to a variety of behavioral changes and mood disorders, Sometimes melatonin disturbance is the sole reason for insomnia or another problem, Melatonin’s effect on body temperature may be one of the keys of its ability to enhance sleep, often there will be complaints of insomnia or frequent waking, Patients with delayed sleep phase insomnia cannot sleep until the early hours of morning, Melatonin deficiency may result in multiple negative effects on an individual's health, Sleep disorders include a range of problems, Research on the melatonin levels in breast and prostate cancer patient has led to support for the contention that melatonin deficiency may be linked to increased risks for these cancers, Your melatonin levels can be tested with a blood test, urine test or saliva test. If you are concerned that you may actually be melatonin deficient People with low melatonin will eventually begin to show signs of wear and tear, Mental effects of a melatonin deficiency are likely to consist of depression, anxiety, stress.
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