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Dehydroepiandrosterone (DHEA) is a multifunctional steroid that plays in a wide range of biological effects in humans and other mammals play a role. Together with its residual sulfate (DHEA-S), it is the most abundant steroid in man. DHEA is produced by adrenal but also synthesized de novo in the brain. It acts on the androgen receptor can both directly and through its metabolites, which androstenediol and androstenedione, the further conversion of the androgen testosterone and estrogens estrone and estradiol produce subject. DHEA is also contained a potent sigma-1 agonist. There will be a neuro steroid

Synonyms and trade names

Synonyms for Dehydroepiandrosterone are:

3-beta-hydroxy-5-androstene-17-one, 3.beta.-Hydroxyandrost-5-en-17-one, 3beta-hydroxy-5-androstene-17-one, 3beta-hydroxy-androst-5-en -17-one, 3beta-Hydroxy-D5-androstene-17-one, 3beta-Hydroxyandrost-5-en-17-one, 3beta-Hydroxyandrost-5-ene-17-one, 3-beta-hydroxy-5-etioallocholan -en-17-one, 5-androstene-3beta-ol-one-17,

Brand names for DHEA include Prastera, Prasterone, Fidelin and Fluasterone. Supplement versions are made from wild Mexican yam.
Dehydroepiandrosterone

Dehydroepiandrosterone sulfate (DHEAS) is the sulfated version of DHEA. This conversion is reversibly catalyzed by sulfotransferase (SULT2A1) primarily in the adrenal glands, liver and small intestine. The blood is on DHEA as DHEAS with levels that are found approximately 300 times higher than those of free DHEA. Orally ingested DHEA-sulfate is its passage through the intestine and liver converted. While natural DHEA levels reach their peak in the early morning hours, DHEAS levels show no diurnal variation. From a practical perspective, the measurement of DHEAS is preferable to DHEA as levels are more stable.

DHEA is produced from cholesterol by two cytochrome P450 enzymes. Cholesterol is converted by the enzyme P450 scc (side chain cleavage pregnenolone), then another enzyme, CYP17A1 converts pregnenolone to 17α-Hydroxypregnenolone and then DHEA.

Dhea role

DHEA can be understood as a prohormone for the sex hormones. DHEAS may be viewed as a buffer and reservoir. As most DHEA by the zona reticularis of the adrenal cortex is produced, it is argued that there is a role in the immune system and stress response.

As almost all DHEA is derived from the adrenal glands, blood measurements of DHEAS / DHEA are useful to detect excess adrenal seen as activity in adrenal hyperplasia and cancer, including some forms of congenital adrenal hyperplasia. Women with PCOS tend to have higher DHEAS.

Studies have shown that DHEA useful in patients with systemic lupus erythematosus. An application of the evidence was discussed by the U.S. Food and Drug Administration in 2001 and is available online. This paper will also show that cholesterol and other blood fats reduce the use of DHEA (mainly a decrease in HDL-cholesterol and triglycerides can in women, p110) is expected.

DHEA supplement has been studied as a treatment for Alzheimer's disease, but proved ineffective. Some small placebo-controlled, randomized clinical trials have long-term supplement to improve mood and relieve depression and found to reduce insulin resistance. reported, however, found a larger placebo-controlled, randomized clinical study in the New England Journal of Medicine in 2006 that DHEA supplementation in older men and women have any positive effects on body composition, physical performance, insulin sensitivity had or improve the quality of life.

In contrast to the non-positive effects of DHEA on memory in the elderly, [a randomized trial in the United Kingdom found that a 7-day course of DHEA (150 mg twice daily) improved episodic memory in healthy young men. This study also showed that DHEA subjective mood and decrease evening cortisol concentrations, which are known in increased depression. The effect of DHEA on memory appeared to be an early activation of the anterior cingulate cortex (ACC) based and it was suggested that this was due to neural recruitment of steroid-sensitive ACC that may be involved in the pre-storage processing hippocampus.

DHEA supplements are sometimes referred to as muscle building or performance-enhancing drugs used by athletes. However, there was a randomized placebo controlled study that DHEA supplementation had no effect on lean body mass, strength or testosterone levels.

A 1986 study found that higher levels of endogenous DHEA, as determined by a single measurement, correlated with a lower risk of death or cardiovascular disease. However, a recent study 2006, no correlation between DHEA levels and risk of cardiovascular disease or death found for men. A 2007 study found the oxidative balance restored DHEA in diabetic patients, reducing the tissue levels of pentosidine for advanced glycation end products biomarkers.

Several in vitro studies showed DHEA, anti-proliferative or apoptotic effect on cancer cell lines. The clinical significance of these findings, if any, is unknown. Higher DHEA, in fact, were at increased risk of developing breast cancer in correlation both pre-and postmenopausal women.

An anonymous review in 2002, in the French journal Prescrire, concluded: DHEA plasma levels are so low, hindering in most animals, they are difficult to measure, studies on DHEA and aging. DHEA is not yet the time of writing, were connected, no specific health problem. Side effects, its androgenic effects, adverse effects associated with lipid metabolism and possible growth-stimulating effect on hormone-dependent tumors. "In practice, there is currently no scientific reason to prescribe DHEA for any purpose."

A 2005 study, measured serum DHEA in 206 men with type 2 diabetes, and found an inverse relationship between serum DHEA and carotid atherosclerosis in men. The authors say the study supports the notion that DHEA, which is sold in more and more as a dietary supplement atheroprotective in humans, and that androgen replacement therapy should be considered in men with hypogonadism. "

A 2006 study supplemented DHEA men averaging 65 years and found that the significant increase in men testosterone and cGMP (cyclic guanosine monophosphate experienced), and a significant decrease in low-density liprotein (LDL). The authors say that suggests the "... findings that chronic DHEA supplement would be antiatherogenic effects, particularly in elderly patients with low blood levels of this hormone to exercise display."

A 2008 study in the Journal of the American Geriatrics Society, June 2008, measured serum DHEA in 940 men and women of 21-88 years after it from 1978 to 2005. The studies found that low DHEA-S significantly associated with shorter life span and showed that higher DHEA-S levels, a "strong predictor for a long life in men are, even after adjusting for age, blood pressure and plasma glucose. No association was found between serum DHEA and longevity for women during the study. The study found no significant difference in life expectancy to 15-year follow-up body, which may note the researchers explain why some previous research that men followed for a period less any relationship found.

Dhea Disputed Effect:

In the United States with DHEA or DHEAS claims that it can be useful to apply for a variety of complaints. DHEA and DHEAS are readily available in the United States, where they are marketed as over-the-counter dietary supplements. A 2004 review in the American Journal of Sports Medicine found that "The marketing of this supplement efficiency far beyond their science. Because DHEA is converted into androstenedione and then testosterone, it has two chances to aromatize into estrogen from androstenedione, estrone and estradiol from testosterone. As such, it is possible to increase the estrogen levels more than testosterone in men.

Increasing endogenous DHEA production:

Regular exercise is known that DHEA-production to increase in the body. Caloric restriction has also been shown to increase DHEA in primates. Some suggest that the increase in endogenous DHEA brought about by caloric restriction is partially responsible for the longer life expectancy, which are known to be associated with caloric restriction in combination.

Dhea isomers:

DHEA (dehydroepiandrosterone) is really a meaningless term scientifically, because it is not descriptive of the actual molecular structure and has a family of structures, lack of hydrogen atoms in one or more points in the molecule. DHEA can be many naturally occurring isomers, that can have similar pharmacological effects. Some good natural isomers of DHEA-dehydroepiandrosterone is a proven (to be synthesized in pigs), 4-dehydroepiandrosterone (I show that in rats), 19NorDHEA (shown to occur in pigs and humans). These isomers are technically DHEA, as it dehydro epiandrosterone (removing hydrogen atoms from the skeleton epiandrosterone).

What is DHEA?:

The production is at the age of 25 years at the highest, and then falls steadily to about 5% of the maximum 85 years. For other steroids is not the case. The first precise determination of DHEA production Beach Life, Skiing, City Breaks place to age in 1958 by Max-Fernand Jaylen, a biochemist at the University of Paris. Women produce more DHEA than men.

The precise biological role is currently more or less understood. Because of its precursor role inter alia for sex hormones DHEA was the role of a buffer hormone attributed Which die availability of other steroids influenced. The addition of DHEA in animal and human experiments showed, however, to include effects of aging, cancer and viral infections.

DHEA has long been known to boost immune function. It is of crucial importance for the development of certain mature immune cells and enhanced antibody production. A new study has found that the number of cells secreting interferon-gamma correlated with serum DHEA levels in men, and that the activity of these cells was associated with DHEA in premenopausal women. Thus, DHEA appears to be involved in the modulation of cytokine production. The same is true for one of its metabolites, androstenediol, which has been shown to protect bone marrow function and resistance to infection following exposure to radiation in rodents even more effective than DHEA. Androstenediol has also been shown to protect against lethal infection with influenza A virus. Since infection produces an increase in cortisol, which in turn suppresses the immune system, it would be logical to try, this counterregulate immunosuppression with antiglucocorticoid as DHEA.

DHEA and cancer:

Between 1972 and 1997, more than 4,000 publications have been published worldwide to DHEA, to 1991, many studies have demonstrated the positive effect against various types of cancer, atherosclerosis, weight reduction and prolonged life span in animals. From 1994 onwards, the effect was mainly investigated in humans and found similar results so far.

In the U.S. and other countries already DHEA is marketed widely and sometimes referred to as a miracle cure. It is slipping out of the mostly very positive recent publications that DHEA-GABEN die Simmung improve, increase sexual activity and readiness to counteract stress hormones, muscle condition to maintain, strengthen the immune system and reduce cancer and heart disease risk. Even against AIDS, osteoporosis and Alzheimer DHEA should be effective.

DHEA should also be closely linked, brain neurons to protect them from age-related degenerative processes such as Alzheimer's. Not only that such degenerative processes occur most frequently when the DHEA levels are lowest, but the concentration of DHEA in the brain is much higher than in blood. Dr. E. Roberts is a specialist in this field of research. He found that small amounts of DHEA are sufficient to increase the number of nerve cells, increasing the number of their contacts with others and their differentiation in culture has its anzuregen.DHEA results show improved long-term memory in trained mice. DHEA may play a similar role in the human brain.

One of the major publications is from Mohammed Kalimi and William Regelson 1990: "The biological role of DHEA, present in about 24 chapters in scientists from around the world the results of perhaps the most important neurotransmitter DHEA. These are impressive. The preface to the Editor can read:

"DHEA affects diabetes, cancer, tumor formation, skin texture, fatigue, depression, memory and immune responses. This latitude range of clinical application, it is surprising why more books have been on DHEA attachments!"

Early studies from England [Bulbrook, 1962.1971] have shown that DHEA appeared in abnormally low concentrations in women who die Had breast cancer, even up to nine years before the disease was diagnosed. From 5000 the study women developed breast cancer 27. Had most of the 27 extremely low DHEA levels. If promoting a low level of DHEA breast cancer, the reverse is also permissible?
The Human Growth Hormone is a peptide hormone (protein) that is used in the pituitary gland (hypophysis) is formed of any healthy person and secreted into the blood to reach all the cells of the body thus. The outstanding effect of growth hormone in children is the stimulation of body growth. Moreover, it also stimulated the protein, fat and bone metabolism in order to allow the growth of the organism through the provision of energy and basic materials. Is not there enough growth hormone or missing it altogether, children remain stunted as adults only and reach heights up to 140 cm. On completion of the expansion, it is for the metabolism of man is the most important "constructive" (anabolic) hormone for muscle, connective tissue and bone. Its importance as a "degrading" hormone in fat metabolism is in the favorable influence of lipids in the blood with a reduction of Artherioskleroserisikos. Drugs with the drug growth hormone (hGH) are among the world's ethical drugs, ie the drugs whose effectiveness is proven and for which there is no substitute.

DHEA and tumors Information:

Dr. A. Schwartz of Temple University, USA found that additions of DHEA in cell cultures from the toxicity of carcinogenic Carcinogenic factors) retained. Typically, cell cultures to respond significantly to DNA mutations, changes in cell appearance and a High mortality. In DHEA-GABEN all these effects were reduced significantly. In mice treated with carcinogenic agents were those who received no DHEA breast cancer. In other studies a reduction of the tumor rate was observed up to 80%. [Schwartz, 1981, 1984] The DHEA-known researcher W. Regelsen stated: "Always when DHEA was tested in a model environment for the development of cancer and tumor-inducing, DHEA had preventive effects."

Although DHEA is currently tested in human tumors, we do not yet know whether the effects in humans are similar.

This must be said that mice and rats were used as test objects for a long time before the investigations in humans. The results so far were mostly similar or identical

DHEA helps fight bacteria and virus, including HIV:

Infection with the Human Immunodeficiency Virus (HIV-1) usually not a full-blown AIDS, except after a period of latency. Certain factors have to activate the virus. These factors include antigens, mitogen and cytokines such as tumor necrosis factor alpha (TNF-alpha). Some experts believe that a State is actually the inflammation with the activation of HIV and AIDS progression for unrestricted exchange of blows. If DHEA has potent anti-inflammatory properties, it should be of great interest to prevent HIV-infected patients, could contribute as a high level of DHEA, that the activation of the virus. Although evidence on the basis of only partial, that advice should HIV patients, their DHEA to be as high as possible seems sound.

In fact, it has been shown that DHEA and its synthetic analogs are capable of producing, in part, inhibition of HIV replication. One study found that a specific analog of DHEA, IM28, had a slightly higher activity against HIV replication as DHEA, but on a prize: Though he was more toxic than DHEA. The mechanism of DHEA's Anti-viral action is not completely understood, but its antioxidant properties (perhaps from the estrogenic metabolites) and their effects on metabolic enzymes are probably part of the explanation.

DHEA hormone research:

Another interesting study to investigate the combined use of DHEA, and melatonin was in Korea. He studied the effects of DHEA, melatonin, and the combination of DHEA and melatonin on the release of tumor necrosis factor alpha (TNF-alpha) by mouse macrophages in the presence of anthrax toxin from the anthrax bacteria. The release of inflammatory cytokines such as TNF-alpha is known to play a central role in the development of anthrax. The authors found that DHEA significantly inhibited the anthrax toxin-induced production of TNF-alpha, melatonin was also effective. The combination of DHEA with melatonin, but did not work better than single therapies.

Simultaneously with the discovery of cancer effect of DHEA, the effect of DHEA on genetically obese mice were studied. Although the DHEA-treated mice ate normally, they remained thin. And lived longer than control mice. In another experiment it was found that even middle-aged fat rats lost weight when fed DHEA-supplemented diet. Diabetes, a typical consequence of obesity, has also been a dramatic return

DHEA and Building Muscle:

Several researchers found that DHEA, the enzyme glucose-6-phosphate dehydrogenase (G6PDH), inhibits an enzyme that breaks down glucose. This will be the so-called pentose phosphate pathway in glucose including ribulose-5-phosphate (converted to nucleotide synthesis) and 3-P-glyceraldehyde, which is re-injected into the glycolysis. Thus, BTS is then formed, which is then converted into acetyl including the precursor of fatty acids and thus the fats. The Pentosephosphatzyklus is particularly relevant in the liver, adipose tissue, adrenal gland, thyroid gland and erythrocytes (red blood cells) play a role, but not in muscles. In most tissues this pathway is, for example, together with the fatty acid synthesis.

Thus DHEA inhibits fat synthesis.

DHEA's antioxidant products:

Furthermore, DHEA stimulates the activity of the antioxidant enzyme catalase in liver, an enzyme that when the material degradation resulting H2O2 (hydrogen peroxide; cytotoxin) breaks down. The entire maturation (stimulation of the formation of mRNA of enzyme genes) of peroxisomes (cell organelles such as: the liver cells), the catalase is contained encouraged. [Mol Pharmacol. 50: 67-74 (1996)]

This antioxidative processes are promoted. [Biochem. J. 301: 753-8 (1994)]

DHEA enhanced combat the formation of interferon-in activated T-cells (white blood cells, the virus-infected cells).

Thus DHEA protects against viral infections.

DHEA promotes the development of insulin-producing cells and increases insulin sensitivity.

DHEA may reduce the Herzinfarktrisioko considerably. Activation of brain metabolism in the forebrain and other brain parts by

DHEA. It can increase the differentiation of nerve cells.

HGH DHEA and melatonin libido products are:

This could be used in women with substitutive Nebennierenschwäche improve well-being and libido in the U.S. dietary supplement DHEA approved: A German-blind placebo controlled study, 24 women showed an know that 50mg / day DHEA die libido and increased sexual Zufriedenheitsignifikant. (New England Journal of Medicine)

DHEA improves obviously the reepithelialization in patients with burns with autologous skin grafts
were treated. In the placebo-controlled trial with 63 patients led DHEA 10 mg / kg intravenously significantly to improved reepithelialization
One week after surgery.

Studies in America:

Researchers at the National Institute of Mental Health of the United States Rockville, Maryland-treated men and 46 women. They received either 90 mg daily for six weeks, DHEA or a dummy treatment (placebo).
As the American journal "Archives of General Psychiatry in March 2005 reported that the depressive symptoms only in the DHEA group improved significantly Hatten. Side effects occurred in this time of taking DHEA not.
In the U.S., DHEA is one-counter dietary supplements. In Germany, you can make DHEA a medical prescription import of a pharmacy or obtain by mail order.

DHEA hormone production:

The production of DHEA in the body falls from about. 30mg of 20 years to less than 6 mg per day at the age of 80. According to Dr. W. Regelson, Medical College Virginia, DHEA is one of the best biochemical marker for the chronological age. In some people from taking DHEA during life by 95%, the biggest decline among the major biochemical substances, which is previously known.

In animal studies DHEA extended the life of rodents by 50%. The animals were living not only longer, looked younger. The gray-haired animals could easily control of the Smooth-haired DHEA-treated animals can be distinguished.

DHEA and heart function:

DHEAS levels correlate directly with mortality (dying) in humans.

in a 12-year study of 240 men aged 50-79 years, researchers found that DHEAS levels are inversely related to mortality, no matter if heart attack or other causes led to the death. A 1mg/Liter-Anstieg in DHEAS concentration corresponded to 48% reduction of mortality a heart attack. Those with a higher blood level of DHEAS were living longer and an Had a lower risk of heart disease. These results point to the conclusion that use of DHEA as a diagnostic standard to predict disease, mortality and age.

Another recent study tested the effects of minimal doses of DHEA (50mg/Tag) in men and women 40-70 years. After 2 weeks the blood pressure level had doubled the people quickly. They slept better, felt more relaxed, more energy and Hatten responded better to stress. As far as a weight loss was found in the 3 months of nothing.

If the studies in animals and humans are true, a DHEA supplement prevent disease, reduce mortality and prolong the life of the people.

DHEA enhances the immune response of the organism has been proven. Oral and especially subcutaneous doses of DHEA have rodents (mice, rats) saved from deadly infections. [. Endocrinol. 150: S209-S220 (1996)]. For example, agents were tested herpes virus type 2, coxsackie virus B4 (CB4)) Epstein Barr virus, West Nile virus, Sindbis virus, Semliki Forest virus, bacteria (Enterococcus faecalis, Pseudomonas aeruginosa), and parasites: (Cryptosporidium parvum).

DHEA is effective against Alzheimer's:

In the U.S. and other countries already DHEA is marketed widely and sometimes referred to as a miracle cure. It is slipping out of the mostly very positive recent publications that DHEA-GABEN die Simmung improve, increase sexual activity and readiness to counteract stress hormones, muscle condition to maintain, strengthen the immune system and reduce cancer and heart disease risk. Even against AIDS, osteoporosis and Alzheimer DHEA should be effective.

DHEA should also be closely linked, brain neurons to protect them from age-related degenerative processes such as Alzheimer's. Not only that such degenerative processes occur most frequently when the DHEA levels are lowest, but the concentration of DHEA in the brain is much higher than in blood. Dr. E. Roberts is a specialist in this field of research. He found that small amounts of DHEA are sufficient to increase the number of nerve cells, increasing the number of their contacts with others and their differentiation in culture has its anzuregen.DHEA results show improved long-term memory in trained mice. DHEA may play a similar role in the human brain.

One of the major publications is from Mohammed Kalimi and William Regelson 1990: "The biological role of DHEA, present in about 24 chapters in scientists from around the world the results of perhaps the most important neurotransmitter DHEA. These are impressive. The preface to the Editor can read:

"DHEA affects diabetes, cancer, tumor formation, skin texture, fatigue, depression, memory and immune responses. This latitude range of clinical application, it is surprising why more books have been on DHEA attachments!"

Early studies from England [Bulbrook, 1962.1971] have shown that DHEA appeared in abnormally low concentrations in women who die Had breast cancer, even up to nine years before the disease was diagnosed. From 5000 the study women developed breast cancer 27. Had most of the 27 extremely low DHEA levels. If promoting a low level of DHEA breast cancer, the reverse is also permissible?

DHEA research info:

Simultaneously with the discovery of cancer effect of DHEA, the effect of DHEA on genetically obese mice were studied. Although the DHEA-treated mice ate normally, they remained thin. And lived longer than control mice. In another experiment it was found that even middle-aged fat rats lost weight when fed DHEA-supplemented diet. Diabetes, a typical consequence of obesity, has also been a dramatic return

Positive effects of DHEA:

Many studies have shown DHEA know that the muscle and promotes bone formation and makes the skin appear young. It also improves neurological function and immune function. There are also indications know that DHEA in heart disease, obesity, cancer and autoimmune diseases (lupus, MS, rheumatoid arthritis) helps and protects against osteoporosis. A study from California (SSCYen) reports know that already after 2 weeks DHEA-taking 82% of women and 67% of men felt an increase in general health. Well as better sleep, more tension and balance, improved handling of stressful situations was one of the positive effects

DHEAS and DHEA in metabolism have apparently diverse effects. Here are some of them:

DHEA as sex hormones:

As a precursor of the adrenal steroid hormones, can be converted into the target organs and tissues depending on the corresponding enzymes in androgens (male sex hormones) and estrogens (female sex hormones). Ca. 50% of the total androgens in men are formed from these two precursors, in women around. Of 75%. The liver converts DHEA to DHEAS in the case of oral intake.

Steroid hormones can easily penetrate the lipid solubility because of your cell membranes, are in the cell bound to a receptor and effect as a hormone receptor complex to the DNA (genetic information) in the nucleus, where genes which can be read and implemented. (Enzyme formation).

DHEA and libido:

This could be used in women with substitutive Nebennierenschwäche improve well-being and libido in the U.S. dietary supplement DHEA approved: A German-blind placebo controlled study, 24 women showed an know that 50mg / day DHEA die libido and increased sexual Zufriedenheitsignifikant. (New England Journal of Medicine)

DHEA improves obviously the reepithelialization in patients with burns with autologous skin grafts
were treated. In the placebo-controlled trial with 63 patients led DHEA 10 mg / kg intravenously significantly to improved reepithelialization
One week after surgery.

DHEA dehydroepiandrosterone:

* To reduce and prevent wrinkles
* Maintain youth and rejuvenation of the skin
* Prevention of aging
* Increase the vitality and joy of life
* Increased power and energy
* Increased sex drive and sexual pleasure
* Dense, full and beautiful hair
* New hair growth in men
* Reduction of menopausal problems
* Strengthening of disease resistance and stress

Dehydroepiandrosterone (DHEA), Prasterone (INN), which is most abundant steroid hormone in humans. Depending on the particular hormone level may be as an estrogen, or as an androgen behavior.

DHEA is the precursor for both the male sex hormones (androgens), and for female sex hormone

DHEA is produced in men to 100% in the inner layer (zona reticularis) of the adrenal cortex. In women there, only about 70% the other 30% occur in the ovaries.

In the biosynthesis of DHEA formed from cholesterol via the intermediate hydroxy-pregnenolone and pregnenolone. Thereafter, the reaction is carried out to 4-androstenedione which is in a chemical equilibrium to testosterone. In a next step may then arise from testosterone 17 β-estradiol. From 4-androstenedione is also possible the synthesis of estrone, which in turn in equilibrium with 17 β-estradiol.

The one formed by the body DHEA levels are the age and sex beach life, skiing, Lastminute, also the concentration of DHEA in the blood of a subject to diurnal rhythm.

The adrenal glands produce in the first few years, only small amounts of a DHEA, larger quantities are first detected in the age of six to seven years. The production of a DHEA reaches its peak around the age of 25 years and then goes back all the time.

In all ages men have slightly higher DHEA levels than women.

DHEA is metabolized in the liver to sulfate DHEA-S (discovered in 1994).

Studies suggest DHEA know that die concentration by a training heart rate variability could be increased and could lead to a corresponding Wirkmuster, as with drugs with anti-depressive effect.

Hgh Growth Hormone (human Growth Hormone:

The Human Growth Hormone is a peptide hormone (protein) that is used in the pituitary gland (hypophysis) is formed of any healthy person and secreted into the blood to reach all the cells of the body thus. The outstanding effect of growth hormone in children is the stimulation of body growth. Moreover, it also stimulated the protein, fat and bone metabolism in order to allow the growth of the organism through the provision of energy and basic materials. Is not there enough growth hormone or missing it altogether, children remain stunted as adults only and reach heights up to 140 cm. On completion of the expansion, it is for the metabolism of man is the most important "constructive" (anabolic) hormone for muscle, connective tissue and bone. Its importance as a "degrading" hormone in fat metabolism is in the favorable influence of lipids in the blood with a reduction of Artherioskleroserisikos. Drugs with the drug growth hormone (hGH) are among the world's ethical drugs, ie the drugs whose effectiveness is proven and for which there is no substitute.

Dhea studies in America:

Researchers at the National Institute of Mental Health of the United States Rockville, Maryland-treated men and 46 women. They received either 90 mg daily for six weeks, DHEA or a dummy treatment (placebo).
As the American journal "Archives of General Psychiatry in March 2005 reported that the depressive symptoms only in the DHEA group improved significantly Hatten. Side effects occurred in this time of taking DHEA not.
In the U.S., DHEA is one-counter dietary supplements. In Germany, you can make DHEA a medical prescription import of a pharmacy or obtain by mail order.

DHEA explanations of its physiological function:

DHEA is unique among the hormones, as there is no specificity for certain hormone receptors hat. With vitamin E we have also found no special metabolic involvement. It has been proved only his role as an antioxidant. DHEA could act in the same way general. Dr. W. Regelsen noted that DHEA may be the first example of a buffering hormone. There is a wide Wirkendes hormone that exerts its effect only under a specific constellation of factors. So it is a hormone buffer against sudden changes of blood pH. Why is man, when you get older, more vulnerable to stress. If the concentration of DHEA declines with age, we lose the buffer against stressrelevante hormone. The buffering effect to protect us from aging. The decrease of DHEA with age may lead to a steady decline of the system that is responsible for establishing the building blocks of new cells, such as lipids, nucleic acids and sex hormones responsible.

Ebeling and VA. Koivisto from the Second Department of Medicine of Helsinki University Hospital in Finland think that DHEA has either estrogen or androgen, depending on the hormonal milieu. There are many hints. In some breast cancer cell lines with low DHEA acts like estrogen and estrogen stimulates tumor growth, while counteracting the absence of estradiol DHEA. Men with an androgenic milieu it acts as an estrogen protects against heart and circulatory diseases.

DHEA dosage information:

Exact doses for humans are not well defined. Daily doses can vary from 5 to 10mg to 2000mg. Up to 6-8 g hat man people try administered without major side effects is recommended to bring their own DHEA and DHEAS concentrations to the level at an early age. And people should take a test to determine his blood pressure level.

Otherwise, are 50-10 mg a good dose. This depends of course on the body's levels, and further from the body's absorption and metabolism. If you feel after a week or man has no effect, you can increase the dose by another 5 mg - 10. This can be achieved as long as until the right blood values.

As a rule, should be sufficient 50 mg for women and 100mg for men to do so.

Micronized DHEA is used mainly in the bloodstream as DHEA (Am. J. Ob. Gyn 1992; 166: 1163 and Am. J. Ob. Gyn 1993; 169: 1536). Specialist at Baylor Medical School USA believe that DHEA, which is absorbed through the skin, is rarely converted into testosterone, DHEA You could also try intranasal.

DHEA supplements except in very high doses, stop the body's own product and

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