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5-HTP L-5-hydroxy tryptophan:
5-HTP is the L-5-hydroxy tryptophan form of the amino acid tryptophan. 5-HTP is 5-HTP in this product in a pure natural state before the toxicological proper extract of Griffonia simplicifolia Africa. The extract acts by its isolated form very quickly, so that the formula is suitable for people who are not even the lack of serotonin, a lack of enzymes. By increasing the serotonin - the mirror depression are treated naturally. This 5-HTP product is just the symptom of the 5-HTP-like defect and immediately and without enzymatic buffer lack of 5-HTP molecules in metabolism. The body needs the hydroxylation of 5-HTP from tryptophan, not to perform themselves. The product makes this a quick, easy and convenient.
5-HTP is not in foodstuffs for any considerable extent. For use as a supplement, it is produced from the seeds of an African plant (Griffonia simplicifolia).
5-HTP therapeutic purposes:
The primary application of 5-HTP for depression. Several small short-term studies have found that there may be as effective as standard antidepressant drugs.1, 2 Since standard antidepressants are also used for insomnia and anxiety, 5-HTP has also been proposed as a treatment for these conditions, but there are only still very preliminary evidence that it works aufzubewahren.3
Even anti-depressants are often used for migraine headaches. Some, but not all studies suggest that regular use of 5-HTP May to reduce the frequency and severity of migraine, as well as help for other types of headaches.4-10 In addition, preliminary evidence that 5-HTP can the symptoms of fibromyalgia11 and perhaps help you lose weight.12-15
What is the scientific evidence for 5-hydroxytryptophan?:
Several small studies have compared 5-HTP was to standard antidepressants.16 The best one a six-week study of 63 people either 5-HTP (100 mg three times daily) or an antidepressant Prozac in the family (fluvoxamine, 50 mg three times daily) .17 Researchers found equal benefit between the supplement and the drug. However, 5-HTP caused fewer and less severe side effects.
5-HTP and migraine and other headaches:
There is some evidence that 5-HTP to prevent May that migraine, when in a dose 400-600 mg daily. Lower doses may not be proven to be effective.
In a 6-month trial of 124 people, 5-HTP (600 mg daily) proved equally effective as the standard drug methysergide.18 The most dramatic benefits were seen reductions in the intensity and duration of migraines. Since methysergide has been better than placebo for migraine headache in previous studies, which provide meaningful study results, but does not airtight, evidence that 5-HTP is also effective.
Similarly good results were obtained in another comparative study, with a different medication and 5-HTP (at a dose of 400 mg daily) .19
However, in one study, 5-HTP (up to 300 mg daily) was less effective than the drug propranolol.20 Also, in a study with children, 5-HTP failed to demonstrate benefit.21 Other studies, which are sometimes cited as evidence that 5-HTP is effective for migraines actually enrolled adults or children with many different types of headaches (including migraine) .22,23,24
Putting all this evidence together, it seems likely that 5-HTP helps people with frequent migraine headaches, when in sufficient doses, but further research must be done. Above all, we need a large double-blind study comparing 5-HTP against placebo over a period of several months.
Finally, an 8-week double-blind, placebo-controlled trial of 65 people (mostly women found) with tension headaches that 5-HTP reduced in a dose of 100 mg three times daily does not significantly the number of headaches experienced, but, They have reduced participants' need another painkilling medications.25
5-HTP and Obesity (Weight Loss)
The drug fenfluramine was a member of the infamous fen-phen now treatment for weight loss. Although very successful, fenfluramine was later associated with damage to the valves of the heart and was withdrawn from the market. Since fenfluramine raises serotonin levels, it seems reasonable to believe that other substances on serotonin may also be useful for weight reduction.
Four small double-blind, placebo-controlled clinical studies examined whether 5-HTP can aid weight loss. The first, a double-blind crossover study found that the use of 5-HTP (at a daily dose of 8 mg per kilogram of body weight) reduced caloric intake despite the fact that the 19 participants to eat is not aware of healthy less.26 Participants given placebo consumed about 2,300 calories per day, while those containing 5-HTP ate only 1,800 calories daily. Use of 5-HTP appeared in a significantly increased satiety after eating. In the course of five weeks, women who lost 5-HTP easily more than 3 lbs.
A follow-up study by the same group enrolled 20 overweight women who try to lose weight.27 Participants received either 5-HTP (900 mg per day) or placebo for two consecutive six-week periods. For the first time, there was no restriction on food, while in the second period, participants were asked, would be expected according to a defined diet that weight loss.
The participants receiving placebo will not lose weight during either period. However obtained, of which 5-HTP about 2% of their initial body weight lost during the no-diet period and an additional 3%, while on the diet. So, a woman lost an initial weight of 170 pounds over 3-1/2 lbs after 6 weeks with 5-HTP without dieting and another 5 lbs while dieting. Once again, participants, the 5-HTP experienced quicker satiety.
Similar benefits have been in a double blind study of 14 obese women received 900 mg of 5-HTP daily.28
Finally, a double-blind, placebo-controlled study found 20 obese people with adult diabetes, the use of 5-HTP (750 mg per day) without intentional dieting resulted in about a 4-1/2 pound weight loss over a two-week period.29 use of 5-HTP reduced carbohydrate intake and fat intake from 75% to a lesser extent.
5-HTP 5-Hydroxytryptophan Introduction:
5-hydroxytryptophan (5-HTP) is an amino acid that the intermediate step between tryptophan and the important brain chemical serotonin. There is a large amount of evidence that suggests that low serotonin levels are a common consequence of modern life. The primary therapeutic applications for 5-HTP is for low serotonin states such as:
* Carbohydrate craving
* Herniated Disc
* Migraine headaches
* Tension headaches
* Chronic daily headache
* Premenstrual syndrome
Although 5-HTP is relatively new to the United States as a dietary supplement, it was in several European countries as a medicine since the 1970s.
What advantages does 5-HTP have over L-tryptophan?
There are many advantages of 5-HTP over L-tryptophan. First of all, because it is a step closer to serotonin, it is more effective. 5-HTP is also to make inherently more secure. Although L-tryptophan is safe if properly prepared and free of the contaminants in conjunction with a severe allergic reaction known as eosinophilia myalgia syndrome (EMS), 5-HTP is a much better choice from a safety and therapeutic perspective. Most commercially available 5-HTP is isolated from a natural source - a seed from an African plant (Griffonia simplicifolia).
5-HTP has been studied in the treatment of depression?
There is excellent documentation that 5-HTP is an effective antidepressant agent. 5-HTP often produces very good results in patients not responding to standard antidepressants. One of the most impressive studies of 99 patients described as suffering from "therapy resistant" depression. 1 These patients had not on previous therapy including all available antidepressant drugs and electroconvulsive therapy treatment. These therapy resistant patients received 5-HTP at dosages averaging 200 mg daily but ranging 50-600 mg per day. Full recovery was, there were 43 of 99 patients and significant improvement was noted in 8 more. This significant improvement in patients with long-standing, no more depression is very impressive that the author of the study to a different state "5-HTP merits a place in the front of the ranks of the antidepressants, rather than as a last resort.
Are there studies that included at 5-HTP directly to antidepressants?
Yes, there are several. 5-HTP is equal to or better than standard antidepressant drugs and the side effects are much less strict. The study, the most important was that compared to fluvoxamine, a "selective serotonin reuptake inhibitors" such as Prozac, Paxil, and Zoloft. In the study, subjects received either 5-HTP (100 mg) or fluvoxamine (50 mg) three times daily for 6 weeks. 3 The percentage decrease in overall depression scores was slightly better in the 5-HTP group (60.7% versus 56.1%). More patients responded to 5-HTP than fluvoxamine and 5-HTP was acting faster than the fluvoxamine.
What effect does 5-HTP for weight loss?
As far back as 1975, researchers showed that the administration of 5-HTP) to rats bred to overeat and are obese to significant reduction of food intake. 4 It turns out that these rats have decreased activity of the enzyme that converts tryptophan to 5-HTP and subsequently to serotonin. In other words, these rats are fat as a result of a genetically determined low level of activity of the enzyme that starts the production of serotonin from tryptophan.
There is much evidence that many humansare genetically predisposed to obesity. This disposition, the same mechanism as genetically predisposed to obesity in rats. In other words, many people are predisposed to obesity in May because it reduced the conversion of tryptophan to 5-HTP and, as a result, decreased serotonin levels. By providing pre-formed 5-HTP, this genetic defect is bypassed and more serotonin is produced. 5-HTP literally turns from hunger. 5
The early animal studies that used 5-HTP as a weight loss aid have been followed by a series of four human clinical studies of overweight women at the University of Rome. 6-9 The first study showed that 5-HTP was able to reduce caloric intake and promote weight loss in spite of the fact that the women conscious effort not to lose any weight. 8 The average amount of weight loss during the five-week period of 5-HTP supplementation was a little more than 3 pounds.
The second study sought to determine whether 5-HTP helped overweight people to diet recommendations. 9 The twelve-week study was conducted in two six-week periods. For the first six weeks there were no dietary recommendations for the second six weeks, the women on a 1,200 calorie diet. As shown in Table 1, the women who took the placebo lost 2.28 pounds, while the women, the 5-HTP lost 10.34 pounds.
As in the previous study, 5-HTP appeared to promote weight loss are consumed with meals by promoting satiety-the feeling of satisfaction leading fewer calories. Any woman who reported the 5-HTP may early.
In the third study with 5-HTP, for the first six weeks there were no dietary restrictions, and for the second six weeks the women were on a 1,200-calorie-per-day diet. 10 The results from this study were more impressive than the previous studies for several reasons. The group, which had lost with the 5-HTP, an average of 4.39 pounds at six weeks and an average of 11.63 pounds in 12 weeks. In comparison, the placebo group had lost an average of only 0.62 pounds and 1.87 pounds at six weeks to twelve weeks. F
Early satiety was reported 100 percent of the subjects during the first six-week period. During the second six-week period, even with severe caloric, ninety percent of the women, the 5-HTP reported early may. Many of the women with the 5-HTP (300 mg three times per day reported), slight nausea in the first six weeks of therapy.
Included in the latest study, 25 overweight non-insulin-dependent diabetes outpatient clinics were included in the study in a double blind, placebo-controlled study and randomized to receive either 5-HTP (750 mg / d) or placebo for two consecutive weeks in which no dietary restriction was prescribed. 9 results again indicated that patients taking 5-HTP significantly decreased their daily energy intake, by reducing carbohydrate and fat intake, and reduced their body weight.
How does 5-HTP compare with melatonin in the treatment of insomnia?
Several clinical studies have shown 5-HTP to get good results in the promotion and maintenance of normal sleep in subjects with insomnia as well. 10-13One of the key benefits with 5-HTP in the treatment of insomnia, sleep is its ability to increase the quality.
How does 5-HTP benefit headache sufferers?
Because chronic headache sufferers have low serotonin in their tissues, some researchers refer to migraine and chronic headaches as a "low serotonin syndrome." 14 There have been several clinical studies with 5-HTP in headaches, including migraine and tension-type headaches that have shown excellent results. 14-20 In particular, the use of 5-HTP in the prevention of migraine headaches significant advantages over drug therapy. Although a number of drugs have proved useful in the prevention of migraine headaches, all of them with significant side effects. In contrast, 5-HTP is very safe.
What is fibromyalgia and how does 5-HTP help?
Fibromyalgia is a disorder recognized recently as a common cause of chronic musculoskeletal pain and fatigue. The history of the development of 5-HTP as an effective treatment for fibromyalgia began with studies on the drug situation fenclonine. 21 The drug blocks the enzyme that converts tryptophan to 5-HTP and as a result blocks serotonin production.
What is the best way to get the 5-HTP?
For depression, weight loss, headaches, fibromyalgia, and the dose should be 50 mg three times per day. If the response is inadequate after two weeks, increase the dose to 100 mg three times per day. This recommendation will greatly reduce the often mild symptoms of nausea during the first weeks of 5-HTP therapy. With enteric-coated capsules or tablets (pills in a way so that it does not dissolve in the stomach) significantly reduces the likelihood of nausea. Because 5-HTP not on the same vehicle as L-tryptophan, it can with food. But if the for weight loss I recommend that it be given 20 minutes before a meal.
Can 5-HTP be taken with St. John's wort extract?
Yes. Working in fact, the two seem very well together. St. John's wort extract has been shown to be about 25 double-blind studies, or as effective as antidepressants in treating mild to moderate depression. In severe cases, I recommend using 5-HTP along with St. John's wort. Make sure that the use of St. John's wort extract standardized for 0.3% hypericin. The dosage for this extract is typically 300 mg three times per day. When used in combination with 5-HTP I recommend 50-100 mg of 5-HTP and St. John's wort extract 150-300 mg three times daily.
What about the use of 5-HTP with antidepressants?
Although 5-HTP has been shown to work very well with antidepressant drugs in clinical trials, my recommendation is that if it is a prescription antidepressant medication, do not take 5-HTP, until you consult with your doctor. It is possible that serotonin levels to high. The result is a condition known as "serotonin syndrome", characterized by confusion, fever, chills, sweating, diarrhea, and muscle spasms.
That being said, your doctor, supervision, 5-HTP can be used in conjunction with antidepressants. The typical dosing schedule is to start with a dose of 5-HTP at 50 mg three times daily, after one month, the dose of antidepressant medication may be halved. If a satisfactory response is achieved after the next month, increasing the dose of 5-HTP to 100 mg three times daily, and there are the drugs. Even your doctor must monitor any change in the dosage of your medication.
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